Correlation of malondialdehyde and hearing threshold level at frequency 4000 Hz post gunshot exposure

Abstract

Background: The incidence of acoustic trauma after gunshot exposure in students of the Sekolah
Polisi Negara (SPN) is quite high. Malondialdehyde (MDA) is a compound that can portray oxidative
stress due to free radicals. The correlation between the levels of MDA and the hearing threshold frequency
post gunshot exposure could be used as the base for administering antioxidants to prevent acoustic
trauma. Objective: To find out the correlation between the levels of MDA and the hearing threshold
frequency post gunshot exposure, in East Java SPN students. Method: An observational analytic study
with a retrospective cross sectional approach using secondary data of medical records of the East Java
SPN students batch 2017/2018. The samples were selected by simple random sampling. Result: Out of
50 students, the mean of age was 19.62 years. All samples were male with mean 559.17 and standard
deviation (SD) 959.86. The calculation of the 4000 Hz frequency threshold value obtained an average
value of 31.52 and SD of 13.4. Hearing loss complaint was found in 1 student (2%). No complaints of
tinnitus and vertigo were found. Statistical tests with Pearson correlation between serum MDA levels and
4000 Hz frequency threshold values showed a correlation coefficient (r) of 0.74 and p = 0.00 (p<0.05).
Conclusion: There was a significant correlation between MDA levels and the hearing threshold at 4000
Hz frequency after gunshot exposure in East Java SPN students.

Keywords: acoustic trauma, malondialdehyde, hearing threshold level at frequency 4000 Hz

ABSTRAK
Latar belakang: Insiden trauma akustik pasca pajanan letusan senjata api pada siswa Sekolah Polisi
Negara (SPN) cukup tinggi. Malondialdehid (MDA) merupakan senyawa yang dapat menggambarkan
stres oksidatif akibat radikal bebas. Adanya hubungan antara kadar MDA dengan nilai ambang dengar
frekuensi 4000 Hertz (Hz) dapat menjadi dasar pemberian antioksidan untuk pencegahan trauma
akustik. Tujuan: Membuktikan hubungan antara kadar MDA dengan nilai ambang dengar frekuensi
4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur. Metode: Penelitian ini adalah
observasional analitik dengan pendekatan retrospektif cross sectional menggunakan data sekunder
berupa rekam medik siswa SPN Jawa Timur angkatan 2017/2018. Sampel dipilih secara simple random sampling. Hasil: Dari 50 siswa, usia rerata adalah 19,62 tahun. Seluruh sampel penelitian adalah laki-laki, rerata=559,17 dan standar deviasi (SD)=959,86. Penghitungan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil nilai rerata=31,52 dan SD=13,4 Keluhan penurunan pendengaran hanya dijumpai pada 1 siswa (2%). Uji statistik dengan korelasi Pearson antara kadar MDA dalam serum dengan nilai ambang dengar frekuensi 4000 Hz didapatkan hasil koefisien korelasi (r) sebesar 0,74 dan p = 0,00 (p<0,05). Kesimpulan: Terdapat hubungan yang signifikan antara kadar MDA dengan nilai ambang dengar frekuensi 4000 Hz pasca pajanan letusan senjata api pada siswa SPN Jawa Timur.

Kata kunci: trauma akustik, malondialdehid, nilai ambang dengar frekuensi 4000 Hz